Synthesis and antimicrobial activity of some new 2-aminomethyl -5-(4-phenyl-5- mercapto-1,2,4-triazol-3-yl)methoxyindole derivatives

Gadaginamath, G S; Patil, SA

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Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/16600

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DC Field	Value	Language
dc.contributor.author	Gadaginamath, G S	-
dc.contributor.author	Patil, SA	-
dc.date.accessioned	2013-03-29T14:27:16Z	-
dc.date.available	2013-03-29T14:27:16Z	-
dc.date.issued	1999-09	-
dc.identifier.uri	http://hdl.handle.net/123456789/16600	-
dc.description	1070-1074	en_US
dc.description.abstract	6-Bromo-2-bromometh yl-1-butyl-3-ethoxycarbonyl-5- ethoxycarbonylmethoxyindole 2 has been prepared from 2-methylindole derivative 1 using NBS as regioselective brominating agent in the presence of radical initiator like dihenzoyl peroxide. Compound 2 is then reacted with amines to yield corresponding 2-aminomethylindole diesters 3a-b. Hydrolysis of 3a-b by ethanolic sodium hydroxide gives the corresponding diacids 4a-b. Diesters 3a-b also react chemoselectively with excess of hydrazine hydrate (99 %) to yield the corresponding monocarbohydrazides 5a-b instead of the expected dicarbohydrazides 6a-b. The monocarbohydrazides 5a-b on reaction with phenylisothiocyanate followed by treatment with NaOH (4 %) solution afford the required 2-aminomethyl-5-(4-phenyl-5-mcrcapto- 1,2,4-triazol- 3-yl )methoxyindole derivatives 5a-b. All the newly synthesised compounds are screened for their antimicrobial activities.	en_US
dc.language.iso	en_US	en_US
dc.publisher	NISCAIR-CSIR, India	en_US
dc.rights	CC Attribution-Noncommercial-No Derivative Works 2.5 India	en_US
dc.source	IJC-B Vol.38B(09) [September 1999]	en_US
dc.title	Synthesis and antimicrobial activity of some new 2-aminomethyl -5-(4-phenyl-5- mercapto-1,2,4-triazol-3-yl)methoxyindole derivatives	en_US
dc.type	Article	en_US
Appears in Collections:	IJC-B Vol.38B(09) [September 1999]

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