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http://nopr.niscpr.res.in/handle/123456789/16626| Title: | Synthesis of purines and azapurines |
| Authors: | Shishoo, C J Jain, K S Jain, S R Shirsath, V S Ravikumar, T |
| Issue Date: | Sep-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The synthesis of a series of C(8) unsubstituled (11a-h), C(8) substituted (12a-e), 8-mercapto (13a-e) 1,3-diaryl-2- thioxanthines, as well as, 8-aza-1,3-diaryl-2-thioxanthines 14a-g, through precursors, 5,6-diamino-1,3-diaryl-2-thiouracils 10 has been reported. Recently, the synthesis of a novel series of 6-amino-1,3-diaryl-2-thiouracils 8 under the influence of dry HCI gas has been reported. 14.15. These compounds are converted to the requisite 5,6-diamino-1,3-diaryl-2-thiouracils 10 via reduction of an intermediate 5-nitroso-6-amino-1,3-diaryl-2-thiouracils 9. Cyclocondensation of 5,6-diamino-2- thiouracils 10 with appropriate one carbon donors afford the desired purines 11-13. |
| Page(s): | 1052-1065 |
| Appears in Collections: | IJC-B Vol.38B(09) [September 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 38B(9) 1052-1065.pdf | 2.1 MB | Adobe PDF | View/Open |
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