<span style="font-size:12.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-ansi-language: EN-IN;mso-fareast-language:EN-IN;mso-bidi-language:AR-SA" lang="EN-IN">Synthesis of new 2-(substituted benzothiazolylcarbamoyl)benzimidazoles as potential CNS depressants</span>

Abstract

The synthesis of a series of 2-(substituted benzothiazolyl-carbamoyl/ benzothiazolylamino-carbamoyl)benzimidazoles <b style="mso-bidi-font-weight: normal">41-60</b> is reported. Their synthesis has been achieved by chloroacetylating the substituted 2-aminobenzothiazoles and 2-

<span style="font-size:12.0pt;font-family:" times="" new="" roman";="" mso-fareast-font-family:"times="" roman";mso-ansi-language:en-in;mso-fareast-language:="" en-in;mso-bidi-language:ar-sa"="" lang="EN-IN">hydrazinobenzothiazoles. The <i style="mso-bidi-font-style:normal">N</i>-chloroacetyl derivatives thus formed have been reacted with <i style="mso-bidi-font-style:normal">o</i>-phenylenediamine in the presence of sulphur to afford the final products. Extension of this sequence of reaction by incorporating certain sulphonamide-hydrazines is also described.</span>