Regioselective reaction: Synthesis and biological activity of some Mannich derivatives

Abstract

<span style="font-size:12.0pt;font-family: " times="" new="" roman";mso-fareast-font-family:"times="" roman";mso-ansi-language:="" en-in;mso-fareast-language:en-in;mso-bidi-language:ar-sa"="" lang="EN-IN">The Mannich reaction of 3-(substituted)-4-(1-phenyl- 3-methyl-5-chloro-4-pyrazolidine)amino-5-mercapto-1, 2, 4-triazoles <b style="mso-bidi-font-weight:normal">3</b> with formaldehyde and appropriate amine results in the regioselective formation of 1-aminomethyl-3- (substituted)-4-(1-phenyl-3-methyl- 5-chloro-4-pyrazolidine)amino-1, 2, 4-triazole-5-thiones <b style="mso-bidi-font-weight:normal">4</b>. The structures of new compounds have been established by analytical and spectral data. These compounds <span style="font-size:12.0pt;font-family:" times="" new="" roman";="" mso-fareast-font-family:hiddenhorzocr;mso-ansi-language:en-in;mso-fareast-language:="" en-in;mso-bidi-language:ar-sa"="" lang="EN-IN">have <span style="font-size: 12.0pt;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:ar-sa"="" lang="EN-IN">been tested for their antifungal and antibacterial activities.</span></span></span>