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http://nopr.niscpr.res.in/handle/123456789/16711| Title: | Synthesis and pharmacological evaluation of 3,5-disubstituted indole-2-[Nβ-(substituted benzopyran-2'-one-3'-carboxyl)]carboxy hydrazides and 2H-3-(various substituted indol-3' -yl)methyl-1 ,3-benzothiazoles |
| Authors: | Mruthyunjayaswamy, B H M Shanthaveerappa, B K |
| Issue Date: | Jun-2000 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Equimolar quantities of 3,5-disubstituted indole-2-carboxy hydrazides 1a-j and diethyl malonate 2 when refluxed in dry xylene for 10hr afford 3,5-disubstituted indole-2-[Nβ-mono(carbethoxy malonoyl)]carboxy hydrazides 3a-j, which on reaction with Bz-substituted salicylaldehydes 4a-d in ethanol under reflux conditions in the presence of catalytic amount of piperidine for 5hr give 3,5-disubstituted indole-2-[Nβ-(substituted benzopyran-2'-one-3' carboxyl)]carboxy hydrazides 5a-z,5a', b'. 2-(Various substituted indol-3'- yl) methyliminothiophenols 8a-d have been synthesised by reacting various substituted indole-3-carboxaldehydes 6a-d and o-aminothiophenol 7. Compounds 8a-d on reduction with sodium borohydride followed by treatment with formaldehyde yield the desired 2H-3-(various substituted indol-3' - yl) methyl-1,3-benzothiazoles l0a-d. All the newly synthesised compounds have been tested for their antimicrobial activity against E.coli,S.aureus, P.vulgaris and A.niger. Also compounds 3b-c, 5b, c, d, h I, s, w and a' and 10a-d have been screened for their analgesic and anticatatonic activity. Some of the compounds exhibit significant activities. |
| Page(s): | 433-439 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.39B(06) [June 2000] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 39B(6) 433-439.pdf | 1.51 MB | Adobe PDF | View/Open |
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