Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/16837| Title: | An efficient method for synthesis of 2-ethyl hexyl-4-methoxy cinnamate: A raw material for cosmetic industry |
| Authors: | Yadav, Vasanti G Chandalia, S B |
| Issue Date: | Jan-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Methyl, ethyl and isopropyl esters of 4-methoxy cinnamic acid could be synthesized by Claisen condensation of anisaldehyde with the respective alkyl acetate at a temperature of 0- 5°C using stoichiometric amount of sodium and a few drops of methanol, the latter being used as an initiator. The yield of the ester of cinnamic acid was about 77%. When the reaction was extended to the synthesis of 2-ethylhexyl ester of cinnamic acid, the reaction rates were rather very poor and it was necessary to carry out the reaction at the temperature of 28°C which resulted in the extensive hydrolysis of the starting acetate and the product ester. In the case of 2-ethyl hexyl ester, therefore, it may be desirable to resort to the synthesis of ethyl/methyl-ester of the cinnamic acid by Claisen condensation followed by transesterification of the ethyl/methyl ester.Thus, transesterification of ethyl 4-methoxy cinnamate with excess of 2-ethyl hexanol and p-toluenesulfonic acid as catalyst at 150°C gave a yield of 93% in 6 h. |
| Page(s): | 19-23 |
| ISSN: | 0975-0991 (Online); 0971-457X (Print) |
| Appears in Collections: | IJCT Vol.06(1) [January 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCT 6(1) 19-23.pdf | 1.14 MB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.