<span style="font-size:12.0pt;line-height: 115%;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language:HI" lang="EN-IN">Role of 5-hydroxytryptamine in <i>Moringa</i> <i>oleifera</i> induced potentiation of pentobarbitone hypnosis in albino rats</span>

Abstract

<span style="font-size:12.0pt;line-height: 115%;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:hi"="" lang="EN-IN">The role of 5-hydroxytryptamine (5-HT) in pentobarbitone (PB ) sleeping time, gross behaviour, electrical activity of the brain and serum 5-HT level was studied in Holtzman strain adult albino rats following treatment with <i>M. oleifera</i> (MO). MO (350mg/kg) caused inhibition of awareness, touch response, motor activity, righting reflex, and grip strength. It significantly increased the PB sleeping time, serum 5-HT level (P<0.001) and α-wave activity. These observations indicate that the aqueous extract of MO potentiated PB induced sleeping time and increased the α-wave activity through 5-HT.</span>