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http://nopr.niscpr.res.in/handle/123456789/17167| Title: | Effect of a polyherbal formulation , Ambrex, on butylated hydroxy toluene (BHT) induced toxicity in rats |
| Authors: | Devi, R S Narayan, Shoba Mohan, K Vijai Sabitha, K E Shyamala Devi, C S |
| Keywords: | Ambrex;BAL (Bronchoalveolar lavage);BHT (Butylated hydroxytoluene);Hepatotoxicity;Lung toxicity;Serum markers |
| Issue Date: | Nov-2003 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Effect of polyherbal formulation Ambrex was evaluated in butylated hydrox ytoluene (BHT) induced toxicity of lungs and liver in rats. Toxicity was produced by administering BHT (500 mg/kg/day) for 3 days. Lung damage was evidenced by elevated levels of broncho alveolar lavage fluid (BAL) parameters such as protein, lactate, lactate dehydrogenase (LDH),alkaline phosphatase (ALP), acid phosphatase (ACP) and glucose-6-phosphate dehydrogenase (G6PDH). Liver damage was proved by elevated levels of serum protein and markers such as LDH, ALP, aspartate amino transferase (A ST), alanine amino transferase (ALT), decreased level of lipid peroxides (LPO) in serum and glutathione (GSH) in liver. Administration of aqueous suspension of Ambrex (50mg/kg orally) retained these elevated level, of BAL-protein, lactate, LDH, ALP, ACP, G6PDH and serum-protein, LDH, ALP, AST and ALT at near normal values . Decreased level of GSH was retained at near normalcy in Ambrex pretreated BHT-administered animals. There was no change in liver LPO in all the four groups. |
| Page(s): | 1294-1299 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.41(11) [November 2003] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 41(11) 1294-1299.pdf | 1.37 MB | Adobe PDF | View/Open |
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