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http://nopr.niscpr.res.in/handle/123456789/17184| Title: | Influence of acidic beverage (Coca-Cola) on pharmacokinetics of ibuprofen in healthy rabbits |
| Authors: | Kondal, Amit Garg, S K |
| Keywords: | Coca-Cola;Ibuprofen;Pharmacokinetics |
| Issue Date: | Nov-2003 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The study was aimed at determining the effect of Coca-Cola on the pharmacokinetics of ibuprofen in rabbits. In a cross-over study, ibuprofen was given orally in a dose of 56 mg/k , prepared as 0.5% suspension in carboxy methyl cellulose(CMC) and blood samples (1ml) were drawn at different time intervals from 0-12 hr. After a wash out period of 7 days,Coca-Cola in a dose of (5 ml/kg) was administered along with ibuprofen (56 mg/kg) and blood samples were drawn from 0-12 hr. To these rabbits, 5 ml/kg Coca-Cola was admini stered once daily for another 7 days. On 8th day,Coca-Cola (5mg/kg) along with ibuprofen (56 mg/kg), prepared as a suspension was administered and blood samples (1ml each) were drawn at similar time intervals. Plasma was separated and assayed for ibuprofen by HPLC technique and various pharmacokinetic parameters were calculated. The Cmax and AUCO-α of ibuprofen were significantly increased after single and multiple doses of Coca-Cola , thereby indicating increased extent of absorption of ibuprofen. The results warrant the reduction of ibuprofen daily dosage, frequency when administered with Coca-Cola. |
| Page(s): | 1322-1324 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.41(11) [November 2003] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 41(11) 1322-1324.pdf | 658.79 kB | Adobe PDF | View/Open |
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