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Abstract

Effect of chronic treatment of standardized aqueous extract of <i>Mori</i><i>ga oleifera </i>(MO) root (100,200,300,350,400,450mg<i>/</i>kg<i>;</i><i> </i>po) on penicillin (PCN) induced convulsion,locomotor behaviour,brain ,serotonin(5-HT), dopamine (DA) and morepinephrine (NE) level was studied in Holtzman strain adult albino rats. The result revealed that pretreatment with MO inhibited PCN -induced, seizure and markedly reduced locomotor activity. Chronic treatment with MO significantly increased the 5-HT and decreased the DA level in cerebral cortex (CC),mid brain (MB), caudate nucleaus (CN) and cerebellum (C B), NE level was, signifi cantly decreased in CC but no appreciable change was observed in MB, CB and CN. Thus , the central inhibitory effect of MO is discussed in the light of the disturbed balance between 5-HT, DA and NE.