Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/17212| Title: | Changes in lipid peroxidation and free radical scavengers in kidney of hypothyroid and hyperthyroid rats |
| Authors: | Sawant, Bilvadaa U Nadkarni, Ganeshsunder D Thakare, Usha R Joseph, Lebana J Rajan, M G R |
| Keywords: | Antioxidant enzymes;Free radical scavengers;Hyperthyroidism;Hypothyroidism;Kidney;Lipid peroxidation;Rats |
| Issue Date: | Nov-2003 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Kidney weight was significantly decreased in hypothyroidism (induced by Na131I administration) and increased in hyperthyroidism (induced by thyroxine treatment) as compared to control in female Wistar rats. The tissue lipid perox idation level remained unchanged in hyperthyroid rats but significantly increased in hypothyroid rats. Superoxide dismutase was decreased in both experimental groups but more so in hyperthyroid rats. Catalase was reduced significantly in hyperthyroid rats but remained unaffected in hypothyroid rats. Tissue glutathione peroxidase (GPx) activity was increased while reduced glutat hione levels remained unaltered in both hypothyroid and hyperthyroid rats. Plasma GPx activity was significantly low in both the hypothyroid and hyperthyroid rats. The results suggest alterations in the oxidative stress in hypothyroid and hyperthyroid rat kidneys with concomitant changes of free radical scavengers. |
| Page(s): | 1334-1337 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.41(11) [November 2003] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 41(11) 1334-1337.pdf | 959.47 kB | Adobe PDF | View/Open |
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