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Title: Evaluation of anti-diarrhoeal activity of hydro alcoholic extract of Chenopodium album L.
Authors: Nigam, Vijay
Paarakh, Padmaa M
Keywords: Chenopodium album;Antidiarrhoeal;Castor oil, PGE2;Intestinal transit;Loperamide;Atropine sulphate
Issue Date: Mar-2013
Publisher: NISCAIR-CSIR, India
IPC Code: Int. cl. (2011.01)−A61K 36/00, A61P 1/12
Abstract: Chenopodium album L. (Chenopodiaceae), a wildly growing plant has been reported to possess number of medicinal properties including treatment of diarrhoea. The purpose of the present study was to evaluate scientifically the anti-diarrhoeal effects of C. album used traditionally in Indian system of medicine. The anti-diarrheal effect of hydro alcoholic (30:70) extract (HEMC) of aerial parts was studied against castor oil-induced-diarrhoea model in rats. The volume of intestinal content induced by PGE2 was studied by enter pooling method. The gastrointestinal transit rate was expressed as the percentage of the longest distance traversed by the charcoal divided by the total length of the small intestine. Like Loperamide (3 mg/kg, orally) there were significant reductions in fecal out put and frequency of droppings when the hydro alcoholic extract of 200 and 400 mg/kg doses were administered orally compared with castor oil treated rats. The plant extracts also significantly retarded the PGE2 induced entero pooling with reduction of volume by 40.34 and 59.88%, respectively. The extract at a dose of 200 and 400 mg/kg significantly inhibited (P<0.01) volume of intestinal content. HEMC and atropine sulphate (0.1 mg/kg) decreased the propulsion of the charcoal meal through the gastrointestinal tract when compared with the control. Distance travelled by the charcoal meal was reduced to 21.91 and 74.80% in the HEMC treated groups with the dose of 200 and 400 mg/kg, respectively, compared to control group. The remarkable anti-diarrhoeal effect of C. album extract against castor oil-induced diarrhoea model, PGE2 enter pooling and intestinal transit by charcoal model attests to its utility in traditional medicine for diarrhoea.
Page(s): 61-66
ISSN: 0976-0512 (Online); 0976-0504 (Print)
Appears in Collections:IJNPR Vol.4(1) [March 2013]

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