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Title: Experimental study on adaptogenic and antiulcer activity of Rasayana Ghana tablet (a tri-herbal formulation) in albino rats
Authors: Deole, Yogesh S
Ashok, B K
Chavan, Sulakshan S
Ravishankar, B
Thakar, A B
Chandola, H M
Keywords: Adaptogen;Antioxidant;Anti-stress;Antiulcer;Tinospora cordifolia;Tribulus terrestris;Emblica officinalis;Rasayana Ghana
Issue Date: Mar-2013
Publisher: NISCAIR-CSIR, India
IPC Code: Int. cl. (2011.01) −A61K 36/00, A61P 1/04
Abstract: Distress is one of the most dangerous epidemics having potential to cause severe somatic and psychiatric disorders. Rasayana (rejuvenation therapy) drugs in Ayurveda can be an answer to prevent stress induced disorders. Rasayana powder, an Ayurvedic formulation, is used for health promoting and anti-ageing benefits. The present study was conducted to evaluate the adaptogenic and antiulcer potency of Rasayana Ghana tablet (RGT) in experimental animals in reverse pharmacological approach. Charles Foster strain albino rats of either sex were divided into five groups and treated as Water control, Stress control, Ghee and Honey treated (Vehicle control), RGT with vehicle control and Standard control. All the animals were subjected to pharmacological protocol of forced swimming stress. RGT was administered along with vehicle in the dose of 180 mg/kg orally for 7 consecutive days before subjecting to stress. The adaptogenic and anti-ulcer activities were assessed on the basis of changes in rectal temperature, body weight, ulcer index, haematological parameters and antioxidant activities. In forced swimming hypothermia, pre-treatment with RGT caused significant attenuation of rectal temperature when compared with both stress control group. The RGT showed significant attenuation on stress induced gastric ulcers by quenching free radicals. Further it significantly prevented stress induced leucopenia. Thus, it can be concluded that RGT along with ghee and honey as vehicle possess anti-stress and adaptogenic activity.
Page(s): 73-80
ISSN: 0976-0512 (Online); 0976-0504 (Print)
Appears in Collections:IJNPR Vol.4(1) [March 2013]

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