Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/17666| Title: | Antidiabetic activity of heart wood of Pterocarpus marsupium Roxb. and analysis of phytoconstituents† |
| Authors: | Mishra, Akansha Srivastava, Rohit Srivastava, Swayam Prakash Gautam, Sudeep Tamrakar, Akhilesh Kumar Maurya, Rakesh Srivastava, Arvind K |
| Keywords: | Antidyslipidemic effect;Antihyperglycemic effect;Glucose uptake;High fat diet;Pterocarpus marsupium heart wood;Skeletal muscle cells |
| Issue Date: | May-2013 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The crude powder, ethanolic extract and aqueous, chloroform, hexane and n-butanol soluble fractions of ethanolic extract of heart wood of P. marsupium showed marked improvement on oral glucose tolerance post sucrose load in normal rats. All these fractions except aqueous fraction showed improvement on oral glucose tolerance post sucrose load on streptozotocin (STZ)-induced diabetic rats. The crude powder, ethanolic extract and hexane and n-butanol fractions showed marked decline in blood glucose level on STZ-induced diabetic rats. The ethanolic extract (100 mg/kg body weight) when given to STZ-induced diabetic rats for 10 consecutive days declined blood glucose, improved OGTT and increased their serum insulin levels. The ethanolic extract also showed marked improvement on oral glucose tolerance on high fat-low dosed STZ-induced diabetic rats and neonatally STZ treated rats. The ethanolic extract of P. marsupium also showed marked antidyslipidemic effects on high fat diet fed Syrian golden hamsters. Altered renal and hepatic function markers and serum insulin levels of high fat diet fed-low dosed STZ-treated diabetic rats were also found towards normalization when these animals were treated with ethanolic extract of P. marsupium for 28 consecutive days. The four out of five phenolic C-glycosides isolated from n-butanol fraction of ethanolic extract of P. marsupium enhanced glucose uptake by skeletal muscle cells (C2C12) in a dose dependent manner. It may primarily be concluded that phenolic-C-glycosides present in P. marsupium heart wood are the phytoconstituents responsible for the antihyperglycemic activity and validate the claim of antidiabetic activity of heart wood of P. marsupium. |
| Page(s): | 363-374 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.51(05) [May 2013] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 51(5) 363-374.pdf | 469.5 kB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.