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http://nopr.niscpr.res.in/handle/123456789/17975| Title: | Kinetics and reactivity of indole-2,3 –dione ring towards alkali in dimethyl sulphoxide-water mixtures |
| Authors: | Fathalla, Magda F Ismail, Amel M |
| Issue Date: | Apr-2006 |
| Publisher: | CSIR |
| Abstract: | Kinetics of alkaline hydrolysis of indole-2,3 -dione (isatin) and indole-2,3-dione (N- melhyl isatin) have been carried out at different percentages of DMSO-H2O mixtures and at different temperatures in the range 30-45°C. The reaction proceeds according to pesudo first-order kinetics. The presence of an electron releasing substituent melhyl group attached to nitrogen atom accelerates the reaction rate. Thermodynamic activation parameters ΔH#, ΔS# and ΔG# have been determined. The negative values of entropy of activation and the non- linear relation between log rate constant and reciprocal of dielectric constant suggest selective solvation by the higher polar water solvent molecules. |
| Page(s): | 901-904 |
| ISSN: | 0975-0975(Online); 0376-4710(Print) |
| Appears in Collections: | IJC-A Vol.45A(04) [April 2006] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCA 45A(4) 901-904.pdf | 775.68 kB | Adobe PDF | View/Open |
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