Evaluation of precompressed grannules prepared for chewable tablets of essential oils as alternative dosage forms

Abstract

Drug delivery systems play an important role in therapeutic performance of medicaments and their commercial success. Further these affect the improvement of medication compliance too. Hence, the comprised research work presents pharmacotechnical investigation of precompressed granules prepared for chewable tablets of peppermint and caraway oils as alternative dosage forms. In India, the two oils are used widely in different forms by common people for the relief of dyspepsia, gastric spasm and carminative purpose in the form of aromatic waters, soft gelatin capsules or as elixirs, moreover the people are taking several products as breath freshener. This approach of formulating these essential oils as chewable tablets enables the patient friendly administration of these oils for therapeutic purposes and provides simultaneously breath freshness to consumer in view of the urban lifestyle increasingly demanding the use of chewables as refreshing agents. Granules for tablet

compression were formulated using hydroxylpropyl cellulose, dicalcium phosphate, mannitol & ProSolve SMCC, and were evaluated for pharmacotechnical parameters and drug content.