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http://nopr.niscpr.res.in/handle/123456789/18716| Title: | Synthesis of biscoupled hemin-thiazoline derivatives and their anticancer activity evaluation |
| Authors: | Sondhi, Sham M Johar, Monika Singh, Nirupma Dastidar, Sunanda G |
| Issue Date: | Jan-2004 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A number of biscoupled hemin-thiazoline derivatives 3a-i have been synthesized and screened in vitro against six human cancer cell lines consisting of lung large (NCIH460), colon (HT29), breast (MCF7 and MCF7/ADR), prostate (DU 145) and CNS (U251) tumors. Compound 3e exhibits good anticancer activity against lung large (NCIH460; GI50 4.3MM), where compound 3g shows good anti cancer activity against colon (HT29; GI50 0.9 μM), breast (MCF7; GI50 0.5μM; MCF7/ADR; GI50 1.8μM), prostate (DU 145; GI50 1.6μM) and CNS (U251; GI50 2.5μM) tumors. |
| Page(s): | 162-167 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.43B(01) [January 2004] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 43B(1) 162-167.pdf | 1.02 MB | Adobe PDF | View/Open |
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