Dissolution studies on tablets of ibuprofen using chitosan

Abstract

An attempt has been made to study the release retardant behaviour of chitosan in ibuprofen tablets. Three different ibuprofen tablets were prepared by using 1, 3 and 5% chitosan paste. <i>In vitro </i>evaluations were carried out by using

dissolution testing apparatus U.S.P (XXI). The dissolution pattern indicated the role of chitosan in sustained release. Bioavailability studies in male beagle dogs clearly showed the sustained nature of release from chitosan based ibuprofen

tablet as compared to conventional ibuprofen marketed formulation. Potential use of chitosan as a new matrix forming material for sustained release preparation has been examined. Chitosan, a natural polysaccharide, has structural characteristics similar to glycosamino glycons. Chitosan has been shown to be non-toxic and biodegradable. It is inexpensive and has been explored in the present investigation as a release retarding agent in ibuprofen tablets.