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http://nopr.niscpr.res.in/handle/123456789/19102| Title: | Potentiality of tricyclic compound thioridazine as an effective antibacterial and antiplasmid agent |
| Authors: | Radhakrishnan, V Ganguly, Kumkum Ganguly, Manju Dastidar, Sujata G. Chakrabarty, A N |
| Issue Date: | Jul-1999 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Thioridazine (Th), which is therapeutically used in psychiatric patients, was found to possess conspi-cuous antimicrobial activity when tested against 316 strains belonging to a number of Gram positive and Gram negative bacteria. Although Staphylococcus aureus, Vibrio cholerae and V. parahaemolyticus were found to be most sensitive, Th was highly bactericidal against S aureus and bacteriostatic for vibrios and other Gram negative organisms. In the study of antiplasmid/curing effect of Th on twelve multiply antibiotic and Th resistant bacteria, it was observed that elimination of R plasmids was facilitated by choice of optimal concentration of Th. Significant elimination of single and combined antibiotic resistances occurred in E. coli and Shigella flexneri and not in S.aureus. |
| Page(s): | 671-675 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.37(07) [July 1999] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 37(7) 671-675.pdf | 951.59 kB | Adobe PDF | View/Open |
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