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http://nopr.niscpr.res.in/handle/123456789/19763| Title: | Oxidative burden and antioxidant defense system in polymorphonuclear leukocytes of human lung diseases |
| Authors: | Sharma, Rashmi N Bhardwaj, A Behera, D Khanduja, K L |
| Issue Date: | Apr-2002 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Superoxide anion (O2.-) and hydrogen peroxide (H2O2) production was significantly higher in blood neutrophils (PMNs) of patients with lung cancer and non-malignant lung diseases when compared to the controls (p<0.001). Superoxide dismutase (SOD) activity was significantly decreased in PMNs of patients with lung cancer (p<0.00l). Similarly, catalase and glutathione peroxidase (GPx) activities were lower in PMNs of lung cancer patients as compared to non-malignant lung diseases and controls. There was an increase in HMP shunt activity as measured by rate of formation of 14CO2 from [1-14C]-glucose in PMNs of lung cancer patients. Modifications in the antioxidant defense system in PMNs of malignant and non-malignant lung diseases, the changes being more in the malignancy are indicated. |
| Page(s): | 124-129 |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Appears in Collections: | IJBB Vol.39(2) [April 2002] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJBB 39(2) 124-129.pdf | 1.45 MB | Adobe PDF | View/Open |
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