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Title: Phytochemical characterization and antibacterial activity of Lindenbergia indica Vatke: A common wall flora against some human pathogens in Doon Valley, Uttarakhand
Authors: Singh, Maneesha
Walia, Shivani
Singh, Arun Kumar
Keywords: Lindenbergia indica;Antimicrobial;Minimum Inhibitory Concentration;Ethnobotany;Human pathogens
Issue Date: Jun-2013
Publisher: NISCAIR-CSIR, India
IPC Code: Int. cl. (2011.01) −A61K 36/00, A61P 31/04
Abstract: The present investigation was carried out on phytochemical characterization and antibacterial activity of Lindenbergia indica Vatke (Family-Scrophulariaceae) which is a perennial herb found to grow on bare rocks and old brick walls in Doon valley. Ethnobotanical studies shows that juice of this plant is used traditionally in chronic bronchitis, sore throat, toothache and is applied to skin eruptions, cuts and wounds. Phytochemical screening of the dried plant extract showed the presence of alkaloids, proteins, carbohydrates, cardiac glycosides, saponins, triterpenoids, tannins and phenols. The antibacterial activity of this plant was carried out using agar disc diffusion method at different concentrations of crude extracts against 12 bacterial strains pathogenic to human beings. Among the seven extracts assayed, acetone and ethanol extracts were found to be most active that exhibit antibacterial activity against most of the studied bacterial strains. Therefore, Minimum Inhibitory Concentration (MIC) of acetone and ethanol extracts was determined against the selected bacterial strains showing zones of inhibition ≥ 10 mm. The results indicate the potential of L. indica Vatke in treating bacterial infections, thus, justifying their traditional use in the treatment of chronic bronchitis, sore throat, toothache and skin eruptions, which are of infectious origin.
Page(s): 138-145
ISSN: 0976-0512 (Online); 0976-0504 (Print)
Appears in Collections:IJNPR Vol.4(2) [June 2013]

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