<span style="mso-bidi-font-size:15.0pt;color:black" lang="EN-GB">Evaluation of anti-diarrhoeal activity of <i style="mso-bidi-font-style: normal">Quisqualis indica</i> L. leaves </span>

Abstract

The aim of the present study is to evaluate the anti-diarrhoeal activity of the petroleum ether extract of leaves of <i>Quisqualis indica</i><span style="mso-bidi-font-style:italic"> L. against experimentally induced diarrhoea. Petroleum ether extract of the drug were evaluated for <span style="mso-bidi-font-style:italic">anti-diarrhoeal activity, using experimentally induced diarrhoea models: castor-oil induced diarrhoea, and charcoal induced gastrointestinal motility test in albino wistar rats of either sex. <span style="mso-bidi-font-style:italic">The earlier reported preliminary phytochemical screening of petroleum ether extracts revealed the presence of alkaloids, glycosides, flavonoids, tannins and phenolic compounds.<span style="mso-bidi-font-style:italic"> petroleum ether extract of <i style="mso-bidi-font-style:normal">Quisqualis indica</i> L. leaves at the doses (100, 200 mg/kg, p.o) were administered through the oral route. The plant extracts exhibited dose dependent anti-diarrhoeal effects in the all treated groups and the results were compared with that of standard drugs (Loperamide (3 mg/kg, p.o) and Atropine sulphate (0.1 mg/kg intraperitoneal), respectively as reference standard drugs. Statistically processed results support the conclusion, that the petroleum ether extracts of <i>Quisqualis indica</i><span style="mso-bidi-font-style:italic"> L. leaves (100 mg/kg and 200 mg/kg) possesses dose dependent, significant (<i style="mso-bidi-font-style:normal">P</i><0.05) antidiarrhoeal activity against experimentally induced diarrhoea.

</span></span></span></span></span>