QSAR study on some synthesized and biologically evaluated glutamine analogs as <span style="font-size:12.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-IN;mso-fareast-language: EN-IN;mso-bidi-language:HI">possible anticancer agents</span>

Abstract

An attempt has been made to identify the chemical structural features required and/or responsible for antitumor activity of 51 different 5-<i>N</i>-substituted-2-<i>N</i>-(substituted benzenesulphonyl) glutamines. For this purpose, a QSAR study has been performed using tumor weight inhibition as the parameter for biological activity. Results show that the steric and the field effects are important for the anticancer activity of these types of glutamine analogs. At least one free hydrogen atom in the amide moiety is required which plays an essential role for the biological activity. The present study will help us in further synthesis of this type of compounds in the future.