Synthesis, characterization, antibacterial and anthelmentic activities of copper(II) complexes with benzofuran Schiff bases

Abstract

Copper(II)chloride reacts with Schiff bases derived from benzaldehydes/acetophenone with 3-amino-2-benzofuran carboxamide/ethyl-3-amino-2-benzofuran carboxylate to yield polymeric complexes of general composition CuLCl₂ (L = Schiff base). The authenticity of the ligands and their complexes has been established by micro analysis, magnetic

susceptibility, IR, electronic, ESR spectral studies and electrical conductance measurements. The ligands act as bidentate, with azomethane nitrogen and carbonyl oxygen atom as donor sites. It is proposed that Cu(II) complexes are polymeric with octahedral geometries. All the ligands and their metal complexes have been screened for antibacterial activity against two

bacteria, viz. <i>S.aureus </i>and <i>E.coli. </i>The complexes of ligands <b>1b, 1f, 1g</b> and <b>1h</b> show promising results against <i>S.aureus. </i>Anthelmentic activity of the ligands and the complexes has been tested on earthworms. The activity is enhanced<i> </i>significantly on complexation.