Transition metal complexes of cis-3,7 -dimethyl-2, 6-octadienthiosemicarbazone: Synthesis, characterization and biocidal studies†

Abstract

Transition metal complexes containing a bidentate N,S donor ligand, i.e., <i>cis</i>-3,7-dimethyl-2,6-octadienthiosemicarbazone (CDOTSC) have been synthesized and characterized by e lemental analysis, molar conductance, magnetic susceptibility measurements and various spectral (IR, eletronic, and ¹H NMR) studies. All the metal complexes are [ML₂Cl₂] type, where M = CO^II, Ni^II, C^II, Zn^II, Cd^II and Hg^II; L = CDOTSC. The ligand CDOTSC acts as a bidentate ligand in all the complexes. Distorted octahedral geometry for Cull complex and octahedral geometries for all other complexes are proposed. The newly synthesized ligand (CDOTSC) and its metal complexes have been screened at 37°C <i>in vitro </i>for their antimicrobi al activity against the bacterial species, <i>Escherichia coli </i>and <i>Staphylococcus aureus</i>,<i> </i>and the fungal strains, <i>Aspergillus niger </i>and <i>Candida albicans. </i>All the complexes and ligand CDOTSC possess strong inhibitory action against bacteria and fungi. The anti microbeal activities of the complexes are stronger than those of ligand CDOTSC itself.