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http://nopr.niscpr.res.in/handle/123456789/20361| Title: | Base mediated 5-endo-dig cyclization of N-propargyl proline derivatives: A facile entry to pyrrolizidine scaffolds |
| Authors: | Mahesh, Sriram Pareek, Manish Ramanjaneyulu, B T Kaur, Gurpreet Anand, R Vijaya |
| Keywords: | Bicyclic compounds;Cyclization;5-endo-dig cyclization;Pyrrolizidine core;Propargyl amines |
| Issue Date: | 3-Aug-2013 |
| Abstract: | A simple, base facilitated 5-endo-dig cyclization strategy has been exploited for the assembly of bicyclic core of pyrrolizidine alkaloids. This unprecedented protocol allows access to a diverse range of alkyl and aryl substituted pyrrolizidine scaffolds in moderate yields from readily available N-propargyl-L-proline ester derivatives under mild conditions. No catalyst or alkyne activator is required to effect this atom economical transformation. |
| Page(s): | 1086-1092 |
| ISSN: | 0975-0975(Online); 0376-4710(Print) |
| Appears in Collections: | IJC-A Vol.52A(08-09) [August-September 2013] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCA 52A(8-9) 1086-1092_Suppl Data.pdf | Supplementary data | 1.81 MB | Adobe PDF | View/Open |
| IJCA 52A(8-9) 1086-1092.pdf | Main article | 166.43 kB | Adobe PDF | View/Open |
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