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Title: Differential microglial and astrocytic response to bacterial and viral infection in the developing hippocampus of neonatal rats
Authors: Patro, Nisha
Singh, Kavita
Patro, Ishan
Keywords: Astrocytes;Infections;Lipopolysaccharide;Microglia;Poly I:C
Issue Date: Aug-2013
Publisher: NISCAIR-CSIR, India
Abstract: Polyinosinic:polycytidylic acid (Poly I:C; 5 mg/kg body weight, ip) and lipopolysaccharide (LPS; 0.3 mg/kg body weight, ip) induced microglial and astrocytic activation in Sprague Dawley rats. Higher microglial and astrocytic activities were noticed in Poly I:C infused rats throughout the hippocampus till postnatal day 21 with a comparatively weaker response in LPS group. However, LPS induced inflammation persisted even after postnatal day 21, indicating thereby, that the Poly I:C (viral mimic) produces an acute inflammation, while LPS (bacterial endotoxin) produces chronic inflammation when exposed during early neonatal life.
Page(s): 606-614
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.51(08) [August 2013]

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