Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/20819| Title: | Microdetermination of anti-hypertensive drug Captopril using 2,6-dichlorophenol indophenol |
| Authors: | Srivastava, Ashutosh Khare, Bindu Argal, Rupali Patel, Sandeep |
| Issue Date: | Dec-2003 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A method has been developed for quantitative microdetermination of antihypertensive drug Captopril in vitro as well as in vivo samples, spectrophotometrically using 2,6-dichlorophenol indophenol [2 ,6-DCPIP). The sulphydryl moiety, of the Captopril is quantitatively oxidized to its corresponding [1,1'-dithiobis'(2-methyl-1-oxopropane-3,1 diyl)bis-L-proline]disulphide by 2,6-DCPIP exhibiting stoichiometry of 2:1. The reaction product has been characterized by FTIR and NMR spectral studies. The method is rapid, accurate with high precision and can be applied for determining drugs in pharmaceutical preparations as well as in-vivo samples. |
| Page(s): | 3036-3040 |
| ISSN: | 0975-0975(Online); 0376-4710(Print) |
| Appears in Collections: | IJC-A Vol.42A(12) [December 2003] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCA 42A(12) 3036-3040.pdf | 984.36 kB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.