Synthesis and characterization of some novel 4-formyl pyrazolylthiazoles of potential medicinal interest using Vilsmeier-Haack reaction

Abstract

Two series of 4-formyl-1, 3-disubstituted pyrazoles namely 2-[3-(2,4-difluorophenyl)-4-formylpyrazol-l-yl]-6-substituted benzothiazoles (<b>3</b>) and 2-[3-(2,4-difluorophenyl)-4-formylpyrazol-lyl]-4-arylthiazoles (<b>7</b>) have been synthesized for evaluation of their antifungal activity through Vilsmeier-Haack reaction on hydrazones (<b>2, 6</b>) of 2,4-difluoroacetophenone with 2-hydrazino-6-substituted benzothiazoles (<b>2</b>) and 2-hydrazino-4-phenyll substituted phenylthiazoles (<b>6</b>). None of the compounds exhibit any significant antifungal activity.