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Title: Cardioprotective effect of root extract of Picrorhiza kurroa (Royle Ex Benth) against isoproterenol-induced cardiotoxicity in rats
Authors: Nandave, Mukesh
Ojha, Shreesh Kumar
Kumari, Santosh
Nag, Tapas Chandra
Mehra, Raj
Narang, Rajiv
Arya, Dharamvir Singh
Keywords: Hemodynamics;Left ventricular dynamics;Lipid peroxidation;Myocardial injury;Oxidative stress
Issue Date: Sep-2013
Publisher: NISCAIR-CSIR, India
Abstract: Normal rats pre-treated with P. kurroa (200 mg/kg) alone did not showed significant change, however, isoproterenol (ISP) administration resulted in hemodynamic and left ventricular dysfunction, oxidative stress, and lipid peroxidation. Such cardiac dysfunction was significantly prevented by P. kurroa root extract pre-treatment. Pre-treatment significantly attenuated the ISP-induced oxidative stress by restoring myocardial superoxide dismutase, catalase, and glutathione peroxidase enzymes except reduced glutathione content. P. kurroa pre-treatment markedly attenuated the ISP-induced rise in lipid peroxidation, thereby prevented leakage of myocyte creatine kinase-MB and lactate dehydrogenase enzymes. The results suggest that P. kurroa root extract possesses significant cardioprotective effect, which may be attributed to its antioxidant, anti-peroxidative, and myocardial preservative properties.
Page(s): 694-701
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.51(09) [September 2013]

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