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http://nopr.niscpr.res.in/handle/123456789/21075| Title: | Cardioprotective effect of root extract of Picrorhiza kurroa (Royle Ex Benth) against isoproterenol-induced cardiotoxicity in rats |
| Authors: | Nandave, Mukesh Ojha, Shreesh Kumar Kumari, Santosh Nag, Tapas Chandra Mehra, Raj Narang, Rajiv Arya, Dharamvir Singh |
| Keywords: | Hemodynamics;Left ventricular dynamics;Lipid peroxidation;Myocardial injury;Oxidative stress |
| Issue Date: | Sep-2013 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Normal rats pre-treated with P. kurroa (200 mg/kg) alone did not showed significant change, however, isoproterenol (ISP) administration resulted in hemodynamic and left ventricular dysfunction, oxidative stress, and lipid peroxidation. Such cardiac dysfunction was significantly prevented by P. kurroa root extract pre-treatment. Pre-treatment significantly attenuated the ISP-induced oxidative stress by restoring myocardial superoxide dismutase, catalase, and glutathione peroxidase enzymes except reduced glutathione content. P. kurroa pre-treatment markedly attenuated the ISP-induced rise in lipid peroxidation, thereby prevented leakage of myocyte creatine kinase-MB and lactate dehydrogenase enzymes. The results suggest that P. kurroa root extract possesses significant cardioprotective effect, which may be attributed to its antioxidant, anti-peroxidative, and myocardial preservative properties. |
| Page(s): | 694-701 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Appears in Collections: | IJEB Vol.51(09) [September 2013] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJEB 51(9) 694-701.pdf | 1.74 MB | Adobe PDF | View/Open |
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