Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/21179| Title: | Stability and thermodynamics of Zn(II)- cysteinemethylester and histidinemethylester system -relevance to zinc core in transcription factor IIIA |
| Authors: | Reddy, P Rabindra Radhika, M |
| Issue Date: | Oct-2000 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The requirements for zinc in the regulation of gene expression is exemplified by transcription factor III A (TF III A) which is a zinc - cysteine protein, containing zinc fingers that bind to DNA. The zinc - core in this protein consisting of Zn - Cysteine - Histidine residues has an important role in the stabilization. Given the ubiquitous occurrence of zinc fingers in biological systems, the stability and thermodynamic parameters associated with the zinc - core have been assessed. The various factors that are responsible for the formation and stabilization of the core are identified. |
| Page(s): | 1030-1035 |
| ISSN: | 0975-0975(Online); 0376-4710(Print) |
| Appears in Collections: | IJC-A Vol.39A(10) [October 2000] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCA 39A(10) 1030-1035.pdf | 1.38 MB | Adobe PDF | View/Open |
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