Microwave assisted synthesis, characterization and antimicrobial studies of unsymmetric imine complexes of organotitanium(IV) and organozirconium(IV)

Abstract

A new class of unsymmetrical organotitanium(IV) and organozirconium(IV) complexes of biologically potent ligands derived from heterocyclic ketones and semicarbazide hydrochloride and 2-hydroxy-N-phenyl benzamide have been prepared by the microwave irradiations. The ligands act in monobasic bidentate manner with N⌒OH and O⌒OH as donor systems. The ligands and the resulting complexes of the type Cp₂M(O⌒O) (N⌒O) (where M represents titanium or zirconium) are characterized by the elemental analysis, conductance measurements, molecular weight determinations and spectral studies. On the basis of the electronic, IR, ¹H NMR and ¹³C NMR spectral studies, octahedral geometry has been proposed for the resulting complexes. The isolated products are coloured solids, soluble in methanol, DMF, DMSO and THF. A comparative study has been made between microwave assisted synthesis and the thermal synthesis. All the complexes and their parent ligands have been screened against a number of microbes and discussed with positive findings.