Synthesis and bioactivity of isoxazolyl thiazoles, isoxazolyl thiazolyl chromen-2-ones, isoxazolyl thiazinanes and isoxazolyl thiazolidinones

Abstract

A series of substituted methyl/phenyl-[4-methyl/carboethoxy/3-(3-methyl-5-styryl-isoxazol-4-yl)-3<i>H</i>-thiazol-2-ylidene]amines <b>3</b>, substituted-3-[2-methyl/ phenylimino-3-(3-methyl-5-styryl-isoxazol-4-yl)-2,3-dihydrothiazol-4-yl]chromen-2-ones <b>4</b>, substituted 5-methyl-2-methyl/phenylimino-3-(3-methyl-5-styryl-isoxazol-4-yl)thiazolidin-4-ones <b>5</b> and substituted methyl/phenyl-[3-(3-methyl-5-styryl-isoxazol-4-yl)-[1,3]-thiazinan-2-ylidenejamines <b>6</b> have been synthesized by the reaction of substituted 1-methyl/phenyl-3-(3-methyl-5-styryl-isoxazol-4-yl)thioureas <b>2</b> with chloroacetone or ethyl bromopyruvate, 3-(ω-bromoacetyl) coumarin, ethyl 2-bromopropionate and 1,3-dibromo- propane, respectively. All the compounds have been evaluated for their antimicrobial activity.