Physicochemical studies on some 4-methylpiperazine-1-carbodithioate complexes of zinc(II), cadmium(II) and mercury(II)

Abstract

New 4-methylpiperazine-1-carbodithioate (4-MPipzcdt) complexes of the general formula [M(4-MPipzcdtX)₂](Y)₂ (M = Zn(II), X = H and Y = ClO₄, Cl; M = Cd(II), Hg(II), X = H and Y = Cl; M = Zn(II), Cd(II), Hg(II) when X and Y = nil) and mixed-ligand complexes, viz. [M(4-MPipzcdtX)a(L)b]Y (L = 1,10-phenanthroline (phen) and 2,2'-bipyridyl (bipy); M = Zn(II), Cd(II), Hg(II), X = H when Y = Cl₂, a = 2, b = 1; M = Zn(II), X = nil where Y = Cl when a = 1, b = 2 and Y = nil when a = 2, b = 1) have been prepared and characterized by elemental analyses, conductance measurements, proton nuclear magnetic resonance, infrared and electronic absorption spectral, and room-temperature magnetic susceptibility measurements. Two of these complexes, viz. Zn(4-MPipzcdt)₂ and [Hg(4-MPipzcdtH)₂](Cl)₂ have been screened for their in vitro antimicrobial activity against the pathogenic fungus Candida albicans and pathogenic gram-negative Escherichia coli, Pseudomonas aeruginosa and gram-positive Staphylococcus aureus, Enterococcus faecalis using the agar dilution method. Two complexes, viz. M(4-MPipzcdt)₂ (M = Zn(II), Cd(II)) have also been screened for their antileukemic activity.