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Title: Stability indicating and simultaneous determination of cinnarizine and piracetam from capsule dosage form by reversed phase high performance liquid chromatography
Authors: Navaneethan, G
Karunakaran, K
Elango, K P
Keywords: Cinnarizine;Liquid chromatography;Piracetam;Peak purity
Issue Date: Sep-2013
Publisher: NISCAIR-CSIR, India
Abstract: A stability indicating reversed phase HPLC assay method has been used for the simultaneous assay of piracetam and cinnarizine drugs in hard gelatin capsule formulation. The separation is achieved by gradient elution using Hypersil BDS C8 column (250 mm × 4.6 mm, i.d. 5 µm particle size) with mobile phase (A) consisting of 0.015 M dipottassium hydrogen phosphate and 2 mL of triethyl amine adjusted at pH 6.0 with orthophosphoric acid and acetonitrile (990:10 v/v); and mobile phase (B) consisting of 2 mL of orthophosphoric acid in 1000 mL of acetonitrile and with a flow rate of 0.6 mL min-1. The retention time is found to be approximately 11 min for PR and 51 min for CN. The analysis is conducted at ambient temperature and monitored using a diode array UV-Vis detector set at wavelength 205 nm. The proposed method is found to be specific, linear, accurate and precise for the simultaneous determination of both the drugs from capsule.
Page(s): 323-326
ISSN: 0975-0991 (Online); 0971-457X (Print)
Appears in Collections:IJCT Vol.20(5) [September 2013]

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