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http://nopr.niscpr.res.in/handle/123456789/21500| Title: | Synthesis and biological activity of some new benzophenothiazines |
| Authors: | Pandey, V K Negi, H S Joshi, M N Bajpai, Ms S K |
| Issue Date: | Jan-2003 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Condensation of carboxylic acids with thiosemicarbazide in presence of conc. H2SO4 gives 2-amino-5-aralkyl-1,3,4-thiadiazoles 1 which on diazotization afford 5-aralkyl-1,3,4- thiadiazolyl-2-diazonium chlorides 2. Reaction of 2 with cold solution of β-naphthol in dilute NaOH furnishes α-(2-diazo-5-aralkyl-1,3,4-thiadiazolyl)-β-sodionaphthoxides 3 which on acidification with conc. HCl gives α-(2-diazo-5-aralkyl-1,3,4-thiadiazolyl)-β-naphthols 4. Reaction of 4 with p-anisidine gives α-(2-diazo-5-aralkyl-1,3, 4-thiadiazolyl)-β-(p-anisidino) naphthalenes 5. Fusion of 5 with sulphur in presence of iodine results in 1-(2'-diazo-5' -aralkyl-1',3',4' -thiadiazolyl)-6-methoxy benzophenothiazines 6 in yields varying from 48% to 59%. The new compounds 6 have been screened for their antiviral and antifungal activities. |
| Page(s): | 206-210 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.42B(01) [January 2003] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 42B(1) 206-210.pdf | 939.38 kB | Adobe PDF | View/Open |
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