One pot reaction: Synthesis, characterization and biological activity of 3-alkyl/aryl-9- substituted 1,2,4-triazolo[3,4-<i>b</i>] [1,3,4]quinolinothiadiazepines

Abstract

Reaction of 6-substituted-2-chloro-3-formylquinoline <b>1</b> and 3-substituted-4-amino-5-mercapto-1,2,4-triazole <b>2</b> gave the novel thiadiazepine derivatives <b>5</b> rather than expected Schiff bases <b>4</b>. Alternatively, compounds <b>5</b> were also prepared by the reaction of <b>2</b> with 6-substitutcri quinolones <b>3</b>. The structures of the newly synthesized compounds have been proposed on the basis of elemental analysis, IR,¹H NMR and mass spectral data. Some of the

new synthetic compounds were also screened for their antibacterial and antifungal activity. Most of them showed significant activity.