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http://nopr.niscpr.res.in/handle/123456789/21513| Title: | Synthesis of isoxazolyl pyrimidine diones & isoxazolyl thiazolidinones |
| Authors: | Rajanarendar, E Afzal, Md Karunakar, D |
| Issue Date: | Feb-2003 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A series of 3-phenyl/methyl-1-(3-methyl-5-styryl/substituted styryl-4-isoxazolyl) -2,3-dihydro-2-thioxo-4,6(1H, 5H) pyrimidinediones 3 have been prepared from 1-phenyl/methyl-4-(3-methyl-5-styryl/substituted styryl-4-isoxazolyl)thioureas 2 by heating with malonic acid in acetyl chloride. Compounds 2 are obtained by interaction of 4-amino-3-methyl- 5-styryl/ substituted styryl isoxazole 1 with phenyl and methyl isothiocyanates. The thioureas 2 when refluxed with chloroacetic acid and sodium acetate in absolute alcohol afford the corresponding 3-(3-methyl-5-styryl/substituted styryl-4-isoxazolyl)-2-phenyl/methyl imino-4-thiazolidinones 4. All the compounds have been evaluated for their biological activity. |
| Page(s): | 353-357 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.42B(02) [February 2003] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 42B(2) 353-357.pdf | 1.01 MB | Adobe PDF | View/Open |
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