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http://nopr.niscpr.res.in/handle/123456789/21523| Title: | Heterocyclic systems containing bridgehead nitrogen atom: Synthesis and bioactivity of 3- (2-thienyl)-s-triazolo[3,4-b] [1,3,4]thiadiazole, 2-(2-thienyl)thiazolo[3,2-b]-s-triazole and isomeric 3-(2-thienyl)-thiazolo[2,3-c]-s-triazole. |
| Authors: | Mohan, Jag |
| Issue Date: | Feb-2003 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The synthesis of 2-(2-thienyl)-5-p-bromophenylthiazolo[3,2-b]-s-triazole 5 has been achieved starting from 5-mercapto-3-(2-thienyl)-s-triazole 3. Compound 3 on condensation with p- bromophenacyl bromide gives the ketone 4 which on cyclization with PPA affords, 5-p-bromophenyl-2-(2-thienyl)thiazolo[3,2-b]-s-triazole 5 and not the isomeric 5-(p-bromophenyl)-3-(2-thienyl)thiazolo[2,3-c]-s-triazole 7. This has been established by an unequivocal synthesis of 7 through POCl3 cyclization of 2- thienoylhydrazino-4-p-bromophenyl thiazole hydrobromide 6. However, the condensation of 4-amino-3-(2-thienyl)-5-mercaptos-triazole 8 with carbon disulphide furnishes 3-(2-thienyl)-striazolo[3,4-b][1 ,3,4]thiadiazole-6(5H)-thione 9 in one step only. The diuretic, antibacterial and antifungal activities of these compounds have also been evaluated. |
| Page(s): | 401-404 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.42B(02) [February 2003] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 42B(2) 401-404.pdf | 792.18 kB | Adobe PDF | View/Open |
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