Synthesis and antimicrobial screening of <i>N-</i>substituted- 3-chloro-4-dithiocarbamato azetidin-2-ones

Abstract

Some new <i>N</i>-substituted-3-chloro-4-dithiocarbamato azetidin-2-ones have been synthesized and their structures are established on the basis of their elemental, IR and ¹H NMR data. All the synthesized compounds have been evaluated for their <i>in-vitro</i> growth inhibitory activity against <i>P. diminuta</i>,<i> B. subtilis, E. coli,</i> <i>S</i>. <i>Aureus, R. rhodochrous. </i>All the compounds show significant antibacterial activity. <i>N</i>-[4' -(<i>N</i>’-4,6-Dimethyl pyrimidinyl) sulphonamoyl amino phenyl]-3-chloro-4-dithiocarbamato azetidin-2-one 2_c has been found to be more potent antimicrobial agent against <i>B. subtilis. </i>A perusal of data reveals that molecular refractive index (M_R) and vander Waal's volume (V_w) are correlated linearly to the drug activity with correlation coefficient of 0.91 and 0.98, respectively. The synthesized compounds have

been subjected to acute toxicity studies to find out LD₅₀ values. The compounds do not show any toxicity up to the dose of 8.5-mg/kg body weights in rats.