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http://nopr.niscpr.res.in/handle/123456789/21528| Title: | Synthesis of isoxazoles and quinoxalines as potential anticancer agents |
| Authors: | Vekariya, N A Khunt, M D Parikh, A R |
| Issue Date: | Feb-2003 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 2-Acetylbenzimidazole on condensation with various aldehydes yield chalcones 1 which on cyclisation with hydroxylaminehydrochloride in sodium acetate furnish 3-(benzimidazol-2'-yl)-5-arylisoxazoles 2a-1. Dibromo derivative of chalcones 1 on reaction with 2-phenylene diamine in sulphuric acid furnish 2-(benzimidazol-2'-yl-methyl)-3-arylquinoxalines 3a-1. The structure of the compounds 3a-1 have been confirmed from elemental analyses, IR, 1H NMR and mass spectral data. The purity of the synthesised compounds have been checked by thin layer chromatography and screened for their antimicrobial and anticancer activity. All the products have been evaluated for their in vitro growth inhibitory activity against different microbes. |
| Page(s): | 421-424 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.42B(02) [February 2003] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 42B(2) 421-424.pdf | 685.16 kB | Adobe PDF | View/Open |
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