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http://nopr.niscpr.res.in/handle/123456789/21544| Title: | Synthesis and cyclooxygenase (COX-1/COX-2) inhibiting property of 3,4-diarylfuranones |
| Authors: | Pal, Manojit Veeramaneni, Venugopal Rao Padakanti, Srinivas Nagabelli, Murali Vanguri, Akhila Mamnoor, Premkumar Casturi, Seshagiri Rao Misra, Parimal Mullangi, Ramesh Yeleswarapua, Koteswar Rao |
| Issue Date: | Mar-2003 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A series of diarylfuranone including some 5-hydroxy derivatives and naphthofuranones have been synthesized as a unique class of COX-1/COX-2 inhibitors. In contrast to the earlier report of structurally similar rofecoxib, these compounds have been characterized as nonselective but highly potent COX inhibitors. Structure Activity Relationship study confirmed that methoxy and methyl sulfanyl moieties are essential for COX activity and replacement or removal of any of this group affect COX-2 potency drastically rather than COX-1 efficacy. Studies on in vitro, in vivo screens and pharmacokinetics are discussed. |
| Page(s): | 593-601 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.42B(03) [March 2003] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 42B(3) 593-601.pdf | 1.85 MB | Adobe PDF | View/Open |
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