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http://nopr.niscpr.res.in/handle/123456789/21669| Title: | Synthesis of novel naphtho[2,1-b]furopyrimidine derivatives |
| Authors: | Mahadevan, K M Vaidya, V P Vagdevi, H M |
| Issue Date: | Aug-2003 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 2-Acyl-3-aminonaphtho[2,1-b]furans 2a-c are converted into corresponding oximes 3a-c ,which on reaction with chloroacetyl chloride in the presence of triethylamine yield 2-chloromethyl-4-alkyl/arylnaphtho[2, 1-b]furo[3,2-d]pyrimidine-3-oxides 4a-c. Acylation of compounds 2a-c furnish 2-acyl-3-acylamidonaphtho[2,1-b]furans 5a-f, which undergo ring closure, on reacting with hydrazine hydrate and produce 2-alkyl/aryl-3,4-dihydro-3-amino-4-hydroxy-4-alkyl/aryl-naphtho[2,l–b]furo[3,2-d]pyrimidines 6a-f. Compounds 6a-f when refluxed with formic acid undergo ring opening and rearrangement simultaneously to give 2-acyl-3-(3'-alkyl/aryl-1',2',4'-triazol-4'-yl)naphtho[2,1-b]furans 7a-f. The compounds synthesized have been screened for antimicrobial anthelmintic and anti-inflammatory activity. |
| Page(s): | 1931-1936 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.42B(08) [August 2003] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 42B(8) 1931-1936.pdf | 1.24 MB | Adobe PDF | View/Open |
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