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http://nopr.niscpr.res.in/handle/123456789/21670| Title: | Synthesis of indoloquinolones, triazoloindoloquinolines and its derivatives |
| Authors: | Mulwad, Y Y Lohar, M Y |
| Issue Date: | Aug-2003 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | 1H,2H-2-Oxo-4-hydrazinoquinolines 1a-e on treatment with cyclohexanone give corresponding 1H,2H-2-oxo-4-quinolinylcyclohexanonehydrazones 2a-e. Thermal Fischer indolization of 2a-e yield 5,6-dihydro-11H-6-oxo-indolo[3,2-c]quinoline 3a-e. Chlorination of 3a-e affords the corresponding chloro compounds 11H-6-chloroindolo [3,2-c] quinolines 4a-e, which on treatment with hydrazine hydrate give 11H-6-indolo [3,2-c] quinolinylhydrazines 5a-e. This hydrazone is used as a building block to synthesize corresponding 3-chloro-1'-(11H-indolo[3,2-c]quinolin-6'yl-amino)-4-(4'-nitrophenyl) azetidin-2-ones 7a-e and 1-phenyl-8H-indolo[3,2-c]quinolin[3',4': 1,2] triazoles 8a-e. 1a-e on treatment with p-nitrobenzaldehyde give 4-quinolinylhydrazono-1-4'-nitrophenyl methanes 9a-e, which on further treatment with chloroacetyl chloride in triethylamine afford 3-chloro- 1'-(4-quinolin-4'yl-amino)-4-(4'-nitrophenyl)azetidin-2-ones 10a-e. Some of these compounds have been screened for their biological activity. |
| Page(s): | 1937-1942 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.42B(08) [August 2003] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 42B(8) 1937-1942.pdf | 1.14 MB | Adobe PDF | View/Open |
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