Synthesis of novel tricyclic heterocyclic compounds as potential anticancer agents using chromanone and thiochromanone as synthons

Hammam, Abou El-Fotooh G; Fahmy, A F M; Amr, Abdel-Galil E; Mohamed, Ashraf M

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DC Field	Value	Language
dc.contributor.author	Hammam, Abou El-Fotooh G	-
dc.contributor.author	Fahmy, A F M	-
dc.contributor.author	Amr, Abdel-Galil E	-
dc.contributor.author	Mohamed, Ashraf M	-
dc.date.accessioned	2013-10-07T11:19:33Z	-
dc.date.available	2013-10-07T11:19:33Z	-
dc.date.issued	2003-08	-
dc.identifier.issn	0975-0983(Online); 0376-4699(Print)	-
dc.identifier.uri	http://hdl.handle.net/123456789/21677	-
dc.description	1985-1993	en_US
dc.description.abstract	The arylmethylene of benzopyrane or benzothiopyrane 3,4 have been synthesized and condensed with hydrazine, guanidine and thiourea to yield pyrazole 5-8, aminopyrimidine 9,10 and thioxopyrimidine derivatives 11,12, respectively. Compounds 3 or 4 on treatment with malononitrile in the presence of ammonium acetate/acetic acid or in the presence of piperidine/ methanol to yield benzopyrano-and benzothiopyranopyridine 13,14 and benzopyrano- and benzothiopyrane 15,16, respectively. The oxirane of compound 3 is prepared and condensed with CS₂ to yield the tricyclic system, thioxothienobenzopyrane 21. Ylidenemalononitrile for the ketone 1 and 2 are synthesized and condensed with aromatic aldehyde in presence of ammonium acetate/acetic acid to yield benzopyranopyridine and benzothiopyranopyridine derivatives 24,25, respectively, which are the isomer of compounds 13,14. Ylidenemalononitrilc on condensation with phenylisothiocyanate yields benzo-pyrano- and benzothiopyranothioxopyridine 28,29, respectively.	en_US
dc.language.iso	en_US	en_US
dc.publisher	NISCAIR-CSIR, India	en_US
dc.rights	CC Attribution-Noncommercial-No Derivative Works 2.5 India	en_US
dc.source	IJC-B Vol.42B(08) [August 2003]	en_US
dc.title	Synthesis of novel tricyclic heterocyclic compounds as potential anticancer agents using chromanone and thiochromanone as synthons	en_US
dc.type	Article	en_US
Appears in Collections:	IJC-B Vol.42B(08) [August 2003]

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