Chemoselective reaction of 1-<i>p</i>-acetanilido-3-acetyl-5-hydroxy-2-methylindole towards methyl chloroacetate :Synthesis and antiinflammatory activity of some new 5- pyrrolyl/oxadiazolyl/triazolyl/quinazolinylmethoxyindole derivatives

Gadaginamath, G S; Pujar, S R; Kavali, R R

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Please use this identifier to cite or link to this item: http://nopr.niscpr.res.in/handle/123456789/21686

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DC Field	Value	Language
dc.contributor.author	Gadaginamath, G S	-
dc.contributor.author	Pujar, S R	-
dc.contributor.author	Kavali, R R	-
dc.date.accessioned	2013-10-07T11:33:55Z	-
dc.date.available	2013-10-07T11:33:55Z	-
dc.date.issued	2003-08	-
dc.identifier.issn	0975-0983(Online); 0376-4699(Print)	-
dc.identifier.uri	http://hdl.handle.net/123456789/21686	-
dc.description	2023-2027	en_US
dc.description.abstract	1-p-Acetanilido-3-acetyl-5-hydroxy-2-methylindole when treated with CH₃I and K₂CO₃ in refluxing dry acetone produces N,O-methylated 1-p-N-methylacetanilido-3-acetyl-5-methoxy-2-methylindole but when it is reacted with methyl chloroacetate under similar reaction conditions yields only O-alkylated 1-p-acetanilido-3-acetyl-5-methoxycarbonylmethoxy-2-methylindole. This indole ester on treatment with hydrazine hydrate in refluxing ethanol gives only the monocarbohydrazide which is reacted separately with acetonyl acetone, triethyl orthoformate. CS₂, KOH/N₂H₄.H₂O, and 1,3-benzoxazine to secure pyrrolyl/oxadiazolyl/triazolyl and quinazolinylmethoxyindoles. Some of these new indole derivatives are screened for their antiinflammatoryactivity.	en_US
dc.language.iso	en_US	en_US
dc.publisher	NISCAIR-CSIR, India	en_US
dc.rights	CC Attribution-Noncommercial-No Derivative Works 2.5 India	en_US
dc.source	IJC-B Vol.42B(08) [August 2003]	en_US
dc.title	Chemoselective reaction of 1-p-acetanilido-3-acetyl-5-hydroxy-2-methylindole towards methyl chloroacetate :Synthesis and antiinflammatory activity of some new 5- pyrrolyl/oxadiazolyl/triazolyl/quinazolinylmethoxyindole derivatives	en_US
dc.type	Article	en_US
Appears in Collections:	IJC-B Vol.42B(08) [August 2003]

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