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http://nopr.niscpr.res.in/handle/123456789/21714| Title: | Synthetic approaches towards 3-pyridinecarbonitrile derivatives and their antimicrobial properties |
| Authors: | Kamel, Mona M Hussein, Manal M M |
| Issue Date: | Sep-2003 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A variety of 2-alkoxy-4,6-diaryl-3-pyridinecarbonitriles 2 have been prepared via either the reaction of 1,3-diaryl-2-propen-1-ones 1 with malononitrile or the reaction of ylidenemalononitriles 6 with the proper aryl methyl ketone 7 in the appropriate alcohol in the presence of sodium. On the other hand, conducting the reaction in refluxing ethanol in the presence of ammonium acetate affords, the corresponding 2-amino-3-pyridinecarbonitriles 8. The antimicrobial properties against Gram-positive, Gram-negative, acid-fast bacteria and yeast have been screened. The prepared propenones 1a-d show considerable activity against the tested yeast as well as most of the Gram-positive and Gram-negative bacteria. A few derivatives of the prepared pyridines 2c,f,h ; 8b exhibit mild antimicrobial activity. |
| Page(s): | 2136-2141 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.42B(09) [September 2003] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 42B(9) 2136-2141.pdf | 291.62 kB | Adobe PDF | View/Open |
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