Synthesis of novel heterocyclic compounds from 6<i>H</i>-[2]-benzopyrano[4,3-c]quinolin-6-one and 2,3-diphenyl furo-[3,2-<i>c</i>]-quinolin-4-(5<i>H</i>)-one

Abstract

11-Chloro-6<i>H</i>-[2]-benzopyrano-[4,3<i>-c</i>]quinolin-6-ones <b>1a-g</b>/4-chloro-2,3-diphenyl-furo[3 ,2-<i>c</i>] quinoline <b>6a-g</b> are obtained via the interaction of 6<i>H</i>-[2]-benzopyran [4,3-<i>c</i>]-quinoline-6, 11-[12]-dione / 2,3-diphenyl-furo[3,2-<i>c</i>]-quinolin-4-(5<i>H</i>)-one with a mixture of phosphorus pentachloride and phosphorusoxychloride. These chloro derivatives are further treated with sodium azide, <i>o-</i>phenylenediamine, anthranilic acid and benzoic acidhydrazide separately to afford novel hetrocyclic compounds 11-methyl-1,2,4-tetrazolo [1', 5', 1,2] quinolino [4,3-<i>c</i>]-benzopyran-8-ones <b>2a-g</b> / 8-methyl-4,5-diphenyl-1,2,4-tetrazolo-[1 ',5': 1,2]-furo[3,2-<i>c</i>]-quinoline <b>7a-g</b>, 13-methyl-imidazolo - [3',2':1,2]-quinolino-[4,3-<i>c</i>]benzopyran-10-ones <b>3a-g</b> / 10-methyl-6, 7 -diphenyl-imidazolo [3',2':1,2]-furo[3,2-<i>c</i>]-quinoline <b>8a-g</b>, 13- methylquinazilono-[3', 2',1,2] quinolino [4,3-<i>c</i>]-benzopyran-10, 16-diones <b>4a-g</b> /10-methyl-6,7 -diphenyl-quinazilono [3', 2', 1,2]furo[3,2-<i>c</i>]quinolin-13-one <b>9a-g</b>, 11-methyl-1-phenyl-triazolo- [3',4':1,2]quinolino [4,3-<i>c</i>]-<i> </i>benzopyran-8-ones <b>5a-g</b> /8-methyl-1-phenyl-4,5-diphenyl-triazolo [3',4':1,2]furo-[3,,2-<i>c</i>]-quinoline <b>10a-g</b> respectively. Some of these compounds have also been screened for their biological activity.