Synthesis, spectral and antimicrobial evaluation of some new 8-membered phosphorus heterocyclic compounds

Abstract

Several new 8-membered phosphours heterocyclic compounds such as 2,10-dichloro-6-aryloxy/arylthio-12-trichloromethyl-12<i>H</i>-dibenzo[d,<i>g</i>][1,3,2] dioxaphosphocin-6-sulfides <b>4a-i</b> have been synthesized by the cyclocondensation of 2,2-bis(2-hydroxy-5-chlorophenyl) 1, 1,1-trichloroethane <b>1</b> with thiophosphorylchloride <b>2</b> in the presence of base in dry toluene followed by addition of different phenols/thiophenols. The chemical structures of all the products are confirmed by analytical, IR, NMR (¹H, ¹³C & ³¹P) and mass spectral studies. Their bio-assay showed them to possess significant antibacterial and antifungal activity.