Please use this identifier to cite or link to this item:
http://nopr.niscpr.res.in/handle/123456789/21726| Title: | Zn(OTf)2-catalyzed three-component, one·pot, condensation reaction: An efficient synthesis of 4-aryl-5-substituted-6-methyl-3,4-dihydropyrimidin-2(1H)-ones |
| Authors: | Xu, Hui Wang, Yan-Guang |
| Issue Date: | Oct-2003 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | An efficient synthesis of 4-aryl-5-substituted-6-methyl-3,4-dihydropyrimidin-2(1H)-ones 4a-n by the reaction of aldehydes 1,1,3-dicarbonyl compounds 2 and urea 3using zinc trifluoromethanesulfonate as a catalyst in refluxing acetonitrile is described. Compared to the classical Biginelli reaction conditions, this new method has the advantages of good yields (71-93%)and short reaction time period (4.5-6.5 hr). |
| Page(s): | 2604-2607 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.42B(10) [October 2003] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 42B(10) 2604-2607.pdf | 671.7 kB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.